Endothelial Progenitor Cell Dysfunction in Cardiovascular Diseases: Role of Reactive Oxygen Species and Inflammation

摘要: Endothelial progenitor cells (EPCs) move towards injured endothelium or inflamed tissues and incorporate into foci of neovascularisation, thereby improving blood flow tissue repair. Patients with cardiovascular diseases have been shown to exhibit reduced EPC number function. It has become increasingly apparent that these changes may be effected in response enhanced oxidative stress, possibly as a result systemic localised inflammatory responses. The interplay between inflammation stress affects the initiation, progression, complications diseases. Recent studies suggest modulate bioactivity. Clinical medications anti-inflammatory antioxidant properties, such statins, thiazolidinediones, angiotensin II receptor 1 blockers, angiotensin-converting enzyme inhibitors, are currently administered patients These appear exert beneficial effects on biology. This review focuses biology explores links inflammation, development