Pharmacogenomics of mood stabilizers in the treatment of bipolar disorder.

摘要: Bipolar disorder (BD) is a chronic and often severe psychiatric illness characterized by manic depressive episodes. Among the most effective treatments, mood stabilizers represent keystone in acute mania, depression, maintenance treatment of BD. However, response highly heterogeneous trait, thus emphasizing need for structured informational framework phenotypic genetic predictors. In this paper, we present current state pharmacogenomic research on long-term BD, specifically focusing stabilizers. While results provided so far support key role factors modulating phenotype, strong evidence predictors still lacking. order to facilitate implementation pharmacogenomics into clinical settings (i.e., creation personalized therapy), further efforts are needed.