Leiomyoma-related bleeding: a classic hypothesis updated for the molecular era

摘要: Leiomyomas are an important cause of menorrhagia and other forms abnormal uterine bleeding. The pathogenesis this process is largely unknown, however. A classic theory, first suggested by Sampson's work in 1912 (Surg. Gynecol. Obstet., 14, 215-230), states that local dysregulation the vascular structures uterus responsible for Recent demonstrates a number growth factors myomatous uterus. As many these regulate angiogenesis or have effects on structures, we hypothesize their receptors provides molecular mechanism underlying abnormalities. In turn, vessels lead women with leiomyomas to experience menorrhagia. Factors may prove be include basic fibroblast factor, endothelial heparin-binding epidermal platelet-derived transforming factor-beta, parathyroid hormone-related protein prolactin. Current treatment regimens leiomyoma-related bleeding depend manipulation steroid hormone environment. By better understanding disease process, therapies directed against factor abnormalities result less harmful side-effects.