Pathogenicity of three isolates of porcine respiratory coronavirus in the USA
作者： P. G. Halbur , F. J. Pallares , T. Opriessnig , E. M. Vaughn , P. S. Paul
关键词: Virology 、 Porcine Respiratory Coronavirus 、 Bronchiolitis 、 Respiratory disease 、 Peripheral blood mononuclear cell 、 Inoculation 、 Biology 、 Bronchointerstitial pneumonia 、 Exudate 、 Pathogenicity 、 General Veterinary 、 General Medicine
摘要: The pathogenicity of three isolates porcine respiratory coronavirus (AR310, LEPP and 1894) from the USA was assessed in specific pathogen-free pigs. Pigs inoculated with 1894 developed mild disease pigs AR31o moderate four to 10 days after they were inoculated, but all recovered fully by 14 inoculation. Gross microscopic examination revealed (1894) (AR31o LEPP) multifocal bronchointerstitial pneumonia lesions characterised necrotising bronchiolitis, septal infiltration mononuclear cells, a mixed alveolar exudate. No clinical signs or observed control that had not been inoculated.
elsevier.com
ed.ac.uk
highwire.org参考文章(19)
E. COX, J. HOOYBERGHS, M.B. PENSAERT, Sites of replication of a porcine respiratory coronavirus related to transmissible gastroenteritis virus. Research in Veterinary Science. ,vol. 48, pp. 165- 169 ,(1990) , 10.1016/S0034-5288(18)30984-6
C Girard, A Jabrane, Y Elazhary, Pathogenicity of porcine respiratory coronavirus isolated in Québec. Canadian Veterinary Journal-revue Veterinaire Canadienne. ,vol. 35, pp. 86- 92 ,(1994)
E M Vaughn, P G Halbur, P S Paul, Sequence comparison of porcine respiratory coronavirus isolates reveals heterogeneity in the S, 3, and 3-1 genes. Journal of Virology. ,vol. 69, pp. 3176- 3184 ,(1995) , 10.1128/JVI.69.5.3176-3184.1995
E M Vaughn, P G Halbur, P S Paul, Three new isolates of porcine respiratory coronavirus with various pathogenicities and spike (S) gene deletions. Journal of Clinical Microbiology. ,vol. 32, pp. 1809- 1812 ,(1994) , 10.1128/JCM.32.7.1809-1812.1994
Theerapol Sirinarumitr, Prem S. Paul, John P. Kluge, Patrick G. Halbur, In situ hybridization technique for the detection of swine enteric and respiratory coronaviruses, transmissible gastroenteritis virus (TGEV) and porcine respiratory coronavirus (PRCV), in formalin-fixed paraffin-embedded tissues Journal of Virological Methods. ,vol. 56, pp. 149- 160 ,(1996) , 10.1016/0166-0934(95)01901-4
P. Vannier, Disorders induced by the experimental infection of pigs with the porcine respiratory coronavirus (P.R.C.V.). Journal of Veterinary Medicine Series B-infectious Diseases and Veterinary Public Health. ,vol. 37, pp. 177- 180 ,(1990) , 10.1111/J.1439-0450.1990.TB01043.X
L. Kim, J. Hayes, P. Lewis, A. V. Parwani, K. O. Chang, L. J. Saif, Molecular characterization and pathogenesis of transmissible gastroenteritis coronavirus (TGEV) and porcine respiratory coronavirus (PRCV) field isolates co-circulating in a swine herd. Archives of Virology. ,vol. 145, pp. 1133- 1147 ,(2000) , 10.1007/S007050070114
M. Pensaert, P. Callebaut, J. Vergote, Isolation of a porcine respiratory, non-enteric coronavirus related to transmissible gastroenteritis. Veterinary Quarterly. ,vol. 8, pp. 257- 261 ,(1986) , 10.1080/01652176.1986.9694050
Kristien Van Reeth, Hans Nauwynck, Maurice Pensaert, Dual infections of feeder pigs with porcine reproductive and respiratory syndrome virus followed by porcine respiratory coronavirus or swine influenza virus: a clinical and virological study. Veterinary Microbiology. ,vol. 48, pp. 325- 335 ,(1996) , 10.1016/0378-1135(95)00145-X
Patrick G. Halbur, Prem S. Paul, Xiang-Jin Meng, Melissa A. Lum, John J. Andrews, John A. Rathje, Comparative Pathogenicity of Nine US Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Isolates in a Five-Week-Old Cesarean-Derived, Colostrum-Deprived Pig Model Journal of Veterinary Diagnostic Investigation. ,vol. 8, pp. 11- 20 ,(1996) , 10.1177/104063879600800103