Effects of continuous haemofiltration on serum enzyme concentrations, endotoxemia, homeostasis and survival in dogs with severe heat stroke

摘要: Abstract Aim To examine the effectiveness of continuous haemofiltration as a treatment for severe heat stroke in dogs. Methods Dogs were randomly allocated to control or group (both n  = 8). Heat was induced by placing anaesthetised dogs high temperature cabin simulator. Upon confirmation (rectal temperature > 42 °C, mean arterial pressure (MAP) decrease > 25 mmHg), removed from chamber and initiated continued 3 h group. observed at room temperature. Results Rectal temperature, haemodynamics, pH, blood gases electrolyte concentrations rapidly returned baseline group, but not After 3 h, rectal 36.68 ± 0.51 °C 39.83 ± 1.10 °C ( P −1 0.23 ± 0.05 EU ml  = 0.003), while malondialdehyde 4.86 ± 0.61 mmol l 8.63 ± 0.66 mmol l Conclusions Continuous reduced body normalised haemodynamics electrolytes, improved serum enzyme increased survival with stroke. may be an effective