INHIBITION OF INSULIN SECRETION BY SOMATOSTATIN
作者： K.G.M.M. Alberti , N. Juel Christensen , S. Engkjær Christensen , AA. Prange Hansen , J. Iversen
DOI: 10.1016/S0140-6736(73)92873-0
关键词: Pancreas 、 Insulin oscillation 、 Beta (finance) 、 Chemistry 、 Insulin 、 Internal medicine 、 Insulin secretion 、 Endocrinology 、 Basal (medicine) 、 Perfusion 、 Somatostatin
摘要: Abstract Injection of somatostatin, the hypothalamic growth-hormone-inhibiting factor, lowered basal plasma-insulin levels. In intravenous glucose-tolerance tests in five normal subjects, glucose-induced insulin release was markedly suppressed and glucose-disappearance rate after somatostatin. Perfusion experiments on isolated canine pancreas showed that somatostatin acts directly beta cells, causing suppression initial late sustained phase.
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