Thrombin generation potential and clot-forming capacity of thawed fresh-frozen plasma, plasma frozen within 24 h and solvent/detergent-treated plasma (octaplasLG® ), during 5-day storage at 1-6°C.
作者： A. Heger , A. Neisser-Svae , L. Trawnicek , D. Triulzi
DOI: 10.1111/VOX.12656
关键词: Emergency situations 、 Plasma 、 Plasma products 、 Solvent 、 Fresh frozen plasma 、 Thrombin generation 、 Thromboelastometry 、 Chemistry 、 Solvent detergent plasma 、 Chromatography
摘要: To enable rapid availability of plasma in emergency situations, the shelf-life thawed fresh-frozen (FFP) has been extended from 24 h to 5 days. The aim this study was evaluate thrombin generation (TG) potential and clot-forming ability during days refrigerated storage FFP, frozen within solvent/detergent-treated octaplasLG® . During for days, TG capacity decreased significantly over time, rotational thromboelastometry showed prolonged clotting times. However, stability studies confirmed comparable vitro haemostatic potentials all three products at day 5.
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