Global haemostasis and point of care testing

摘要: Summary.  The evaluation of the coagulation profile has used so far either clotting-based or chromogenic assays with different endpoints. Clotting-based techniques are most worldwide, and they certainly useful for diagnosis clotting factor deficiencies. However, information provided is relatively limited, therefore individual poorly assessed. This reflected by weak correlation between results these clinical phenotype. Among that benefited from technological advances, thrombin generation thromboelastography probably actively investigated, but require specific instruments not fully automated. Their standardisation level rapidly progressing, progressively entering scene, attempt to provide additional on process a meaningful correlation. These inherited bleeding disorders frequently replacement therapy using concentrates increase plasma missing factor. classical adjustment mainly based measurement activity protein administered. If one considers certain generated would predict efficacy, monitoring formation might offer new possibilities individually phenotype, select adapted therapeutic product tailor dose. same holds true thromboelastography/thromboelastometry which evaluate fibrin as well clot resistance fibrinolytic challenge, step further down in process. In this regard, 2 could be seen complementary terms at level.