Assay of T- and NK-cell subsets and the expression of NKG2A and NKG2D in patients with new-onset systemic lupus erythematosus.
作者： Wen-Xian Li , Hai-Feng Pan , Jian-Li Hu , Chang-Zhong Wang , Ning Zhang
DOI: 10.1007/S10067-009-1322-9
关键词: Endocrinology 、 Lupus erythematosus 、 IL-2 receptor 、 CD8 、 NKG2D 、 Internal medicine 、 Immunology 、 T cell 、 CD3 、 Peripheral blood mononuclear cell 、 Medicine 、 CD16
摘要: This study aims to explore the percentage of T-cell and NK-cell subsets, expression NKG2A NKG2D on CD3+ T cells CD3−CD56+ NK total lymphocytes in new-onset systemic lupus erythematosus (SLE) patients, clinical significance these cell subsets. Thirty-two SLE patients 32 normal controls were enrolled. Flow cytometry was used count T- subsets detect with SLE. Results show that CD4+ (t = 2.04, P < 0.05), CD4+/CD8+ 2.66, CD25+ 2.48, CD3+CD56+ natural killer (NKT) 40.05, 0.01), CD3−CD56+CD16+ 3.50, 0.01) significantly decreased, CD8+ increased 3.80, as compared healthy controls. subset vasculitis 2.47, arthritis 3.21, 0.01). However, no statistically significant correlation found among different PBMC SLEDAI activity scores. Patients had a lower (U 2.42, 0.05) well NKG2A/NKG2D ratio 2.61, higher 2.21, cells, they 2.59, 49.45, 3.05, cells. Taken together, findings indicate decreased T-cell, CD4+CD25+ NKT-, abnormal CD3−CD56 + may play role etiology
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sci-hub.se 参考文章(38)
L L Lanier, C Chang, S Lazetic, J P Houchins, J H Phillips, Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits. Journal of Immunology. ,vol. 157, pp. 4741- 4745 ,(1996)
Ethan M. Shevach, CD4+CD25+ suppressor T cells: more questions than answers Nature Reviews Immunology. ,vol. 2, pp. 389- 400 ,(2002) , 10.1038/NRI821
Laurent Gapin, Jennifer L. Matsuda, Charles D. Surh, Mitchell Kronenberg, NKT cells derive from double-positive thymocytes that are positively selected by CD1d Nature Immunology. ,vol. 2, pp. 971- 978 ,(2001) , 10.1038/NI710
Fu-Dong Shi, Hua-Bing Wang, Hulun Li, Seokmann Hong, Masaru Taniguchi, Hans Link, Luc Van Kaer, Hans-Gustaf Ljunggren, Natural killer cells determine the outcome of B cell–mediated autoimmunity Nature Immunology. ,vol. 1, pp. 245- 251 ,(2000) , 10.1038/79792
Kjell Eneslãtt, Solbritt Rantapãã-Dahlqvist, Agneta Uddhammar, Karl-gõsta Sundqvist, The Regulation of FasL Expression—A Distinguishing Feature Between Monocytes and T Lymphocytes/NK Cells with Possible Implications for SLE Journal of Clinical Immunology. ,vol. 21, pp. 183- 192 ,(2001) , 10.1023/A:1011035115342
Feza Erkeller-Yüksel, Frank Hulstaart, Irene Hannet, David Isenberg, Peter Lydyard, Lymphocyte Subsets in a Large Cohort of Patients with Systemic Lupus Erythematosus Lupus. ,vol. 2, pp. 227- 231 ,(1993) , 10.1177/096120339300200404
Jyh-Hong Lee, Li-Chieh Wang, Yu-Tsan Lin, Yao-Hsu Yang, Dong-Tsamn Lin, Bor-Luen Chiang, Inverse correlation between CD4+ regulatory T-cell population and autoantibody levels in paediatric patients with systemic lupus erythematosus Immunology. ,vol. 117, pp. 280- 286 ,(2006) , 10.1111/J.1365-2567.2005.02306.X
Yong‐Wook Park, Seung‐Jung Kee, Young‐Nan Cho, Eun‐Hee Lee, Hwa‐Youn Lee, Eun‐Mi Kim, Min‐Ho Shin, Jeong‐Jin Park, Tae‐Jong Kim, Shin‐Seok Lee, Dae‐Hyun Yoo, Hyung‐Sik Kang, None, Impaired differentiation and cytotoxicity of natural killer cells in systemic lupus erythematosus. Arthritis & Rheumatism. ,vol. 60, pp. 1753- 1763 ,(2009) , 10.1002/ART.24556
Julia Szekeres-Bartho, Aliz Barakonyi, Eva Miko, Beata Polgar, Thomas Palkovics, The role ofγ / δT cells in the feto-maternal relationship Seminars in Immunology. ,vol. 13, pp. 229- 233 ,(2001) , 10.1006/SMIM.2000.0318
Ingrid B�hm, Nuclear-targeting autoantibodies induced nuclear PARP cleavage accompanied by more pronounced decrease of peripheral white blood cells than Ro/SSA and La/SSB antigen-targeting autoantibodies. Journal of Clinical Immunology. ,vol. 25, pp. 99- 105 ,(2005) , 10.1007/S10875-005-2815-1