Cellular effects of transferrin coordinated to [Cl(NH3)5Ru]Cl2 and cis-[Cl2(NH3)4Ru]Cl
作者： Dominic R. Frasca , Lauren E. Gehrig , Michael J. Clarke
DOI: 10.1016/S0162-0134(00)00180-X
关键词: DNA 、 Imidazole 、 Dissociation (chemistry) 、 Stereochemistry 、 Ruthenium 、 Transferrin 、 Jurkat cells 、 Binding site 、 Chemistry 、 Moiety
摘要: Abstract Estimates of the net equilibrium binding constants for [(H 2 O)(NH 3 ) 5 Ru II ] 2+ , [Cl(NH III cis -[(H O) (NH 4 and -[Cl + with apotransferrin (Tf) holotransferrin (Fe Tf) suggests that but not complexes bind a higher affinity to iron sites. Several other presumably histidyl imidazole sites approximately same ( K eff =10 10 M −1 both . Compared HeLa cells, an order magnitude level nuclear DNA ([Ru] /[P] was required achieve toxicity in Jurkat T ag which probably relates substantially levels Ru] needed inhibit 50% cell growth line. Against pentaammineruthenium(III) group is enhanced by two orders upon primarily Fe-sites apotransferrin, whereas tetraammineruthenium(III) moiety only marginally increased. Binding Fe Tf does increase either group. Significant dissociation over 24 h ammineruthenium(III) ions from requires reduction
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