The Ruthenium Complex cis -(Dichloro)tetraammineruthenium(III) Chloride Presents Selective Cytotoxicity Against Murine B Cell Lymphoma (A-20), Murine Ascitic Sarcoma 180 (S-180), Human Breast Adenocarcinoma (SK-BR-3), and Human T Cell Leukemia (Jurkat) Tumor Cell Lines
作者： Elisângela de Paula Silveira-Lacerda , Cesar Augusto Sam Tiago Vilanova-Costa , Amélia Hamaguchi , Luiz Alfredo Pavanin , Luiz Ricardo Goulart
DOI: 10.1007/S12011-009-8498-3
关键词:
摘要: The aim of present study was to verify the in vitro antitumor activity a ruthenium complex, cis-(dichloro)tetraammineruthenium(III) chloride (cis-[RuCl2(NH3)4]Cl) toward different tumor cell lines. studies showed that ruthenium(III) complex presents relevant cytotoxic against murine B lymphoma (A-20), ascitic sarcoma 180 (S-180), human breast adenocarcinoma (SK-BR-3), and T leukemia (Jurkat) lines very low cytotoxicity peripheral blood mononuclear cells. decreased fraction cells G0/G1 and/or G2-M phases, indicating this compound may act on resting/early entering precycling high concentration (2 mg mL−1) cis-[RuCl2(NH3)4]Cl Jurkat correlated with an increased number annexin V-positive also presence DNA fragmentation, suggesting induces apoptosis development new antineoplastic medications demands adequate knowledge order avoid inefficient or toxic treatments. Thus, mechanistic understanding how metal complexes achieve their activities is crucial clinical success rational design compounds improved potency.
springer.com
cabdirect.org
sci-hub.se 参考文章(54)
F. Kratz, M. Hartmann, B. Keppler, L. Messori, The binding properties of two antitumor ruthenium(III) complexes to apotransferrin. Journal of Biological Chemistry. ,vol. 269, pp. 2581- 2588 ,(1994) , 10.1016/S0021-9258(17)41984-3
Joseph Alroy, Vibha Goyal, Angelo A. Ucci, George T. Klauber, John A. Heaney, Samuel M. Cohen, Cell surface coat of human and rat bladder urothelium Virchows Archiv B Cell Pathology Including Molecular Pathology. ,vol. 42, pp. 251- 262 ,(1983) , 10.1007/BF02890388
Viktor Brabec, DNA modifications by antitumor platinum and ruthenium compounds: their recognition and repair. Progress in Nucleic Acid Research and Molecular Biology. ,vol. 71, pp. 1- 68 ,(2002) , 10.1016/S0079-6603(02)71040-4
V Scarcia, G Sava, A Furlani, R Gagliardi, E Alessio, A Bergamo, G Mestroni, In vitro cell cycle arrest, in vivo action on solid metastasizing tumors, and host toxicity of the antimetastatic drug NAMI-A and cisplatin. Journal of Pharmacology and Experimental Therapeutics. ,vol. 289, pp. 559- 564 ,(1999)
Bastiano Sanna, Marcella Debidda, Gianfranco Pintus, Bruna Tadolini, Anna M. Posadino, Federico Bennardini, Gianni Sava, Carlo Ventura, The anti-metastatic agent imidazolium trans-imidazoledimethylsulfoxide-tetrachlororuthenate induces endothelial cell apoptosis by inhibiting the mitogen-activated protein kinase/extracellular signal-regulated kinase signaling pathway Archives of Biochemistry and Biophysics. ,vol. 403, pp. 209- 218 ,(2002) , 10.1016/S0003-9861(02)00218-7
Elisângela de Paula Silveira-Lacerda, Cesar Augusto Sam Tiago Vilanova-Costa, Flávia de Castro Pereira, Amélia Hamaguchi, Luiz Alfredo Pavanin, Luiz Ricardo Goulart, Maria Inês Homsi-Brandenburgo, Andreimar Martins Soares, Wagner Batista dos Santos, Auro Nomizo, None, The Ruthenium Complex cis-(Dichloro)Tetraammineruthenium(III) Chloride Presents Immune Stimulatory Activity on Human Peripheral Blood Mononuclear Cells Biological Trace Element Research. ,vol. 133, pp. 270- 283 ,(2010) , 10.1007/S12011-009-8440-8
G. Sava, S. Zorzet, T. Giraldi, G. Mestroni, G. Zassinovich, Antineoplastic activity and toxicity of an organometallic complex of ruthenium(II) in comparison with cis-PDD in mice bearing solid malignant neoplasms European Journal of Cancer and Clinical Oncology. ,vol. 20, pp. 841- 847 ,(1984) , 10.1016/0277-5379(84)90223-2
Italo Zanzi, Suresh C. Srivastava, George E. Meinken, William Robeson, Leonard F. Mausner, Ralph G. Fairchild, Donald Margouleff, A new cholescintigraphic agent: ruthenium-97-DISIDA. International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology. ,vol. 16, pp. 397- 403 ,(1989) , 10.1016/0883-2897(89)90107-4
Dick Pluim, Robert C. A. M. van Waardenburg, Jos H. Beijnen, Jan H. M. Schellens, Cytotoxicity of the organic ruthenium anticancer drug Nami-A is correlated with DNA binding in four different human tumor cell lines. Cancer Chemotherapy and Pharmacology. ,vol. 54, pp. 71- 78 ,(2004) , 10.1007/S00280-004-0773-6
Thomas M. Buttke, Paul A. Sandstrom, Oxidative stress as a mediator of apoptosis Immunology Today. ,vol. 15, pp. 7- 10 ,(1994) , 10.1016/0167-5699(94)90018-3