DNA Topoisomerase II: Promising Target for Anticancer Drugs

摘要: Topoisomerase II inhibitors are being researched as targets for the generation of antineoplastic drugs because inhibition topoisomerase by theses leads to cell death. Inhibitors bind with molecule thus making enzyme nonfunctional and converting it into a cellular toxin that fragments genome. Cancer cells divide more rapidly than normal cells. Thus, cancer would be killed preferably instead inhibitors. The which decrease overall activity this called catalytic increase level topoisomerase–DNA-cleaved complexes poisons. poisons further divided intercalating non-intercalating. Phytochemicals have proven rich sources widely used anticancer drugs, whereas some components human diet known act chemopreventive agents. present review explains role both categories inhibitors, viz., poisons, their in chemoprevention.