Genetics of human sperm.
作者： Renée H. Martin
关键词: Chromosome abnormality 、 Aneuploidy 、 Sperm 、 Andrology 、 Chromosome 21 、 Chromosome 、 Biology 、 Ploidy 、 Genetics 、 Infertility 、 Fluorescence in situ hybridization
摘要: Purpose:Chromosome abnormalities in sperm were studied by fluorescence situ hybridization to determine the frequency and distribution of normal men effect donor age on abnormalities. Studies chemotherapy infertility patients assessed any increased risk these populations. Methods:Multicolor was performed samples assess aneuploidy frequencies for chromosomes 1, 2, 4, 9, 12, 13, 15, 16, 18, 20, 21, X, Y as well “sex ratios” diploid sperm. Results:Most yielded disomy estimates approximately 0.1%, whereas chromosome 21 sex significantly elevated. The only show a significant paternal YY disomy. Chemotherapy did not have an aneuploid 2–13 years after treatment. Infertility had XY. Conclusions:Multicolor analysis allows comparison from various populations has demonstrated that infertile increase sperm.
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