Polymyxin B containing polyion complex (PIC) nanoparticles: Improving the antimicrobial activity by tailoring the degree of polymerisation of the inert component.
作者： Ignacio Insua , Laimdota Zizmare , Anna F. A. Peacock , Anne Marie Krachler , Francisco Fernandez-Trillo
DOI: 10.1038/S41598-017-09667-3
关键词: Styrene 、 Polymyxin B 、 Antimicrobial 、 Chemistry 、 Nanoparticle 、 Drug carrier 、 Polyelectrolyte 、 Polymer 、 Electrolyte 、 Chemical engineering
摘要: Here, we describe the preparation and characterisation of polyion complex (PIC) nanoparticles containing last resort antimicrobial polymyxin B (Pol-B). PIC were prepared with poly(styrene sulphonate) (PSS) as an inert component, across a range degrees polymerisation to evaluate effect that multivalency this electrolyte has on stability activity these nanoparticles. Our results demonstrate while longer polyelectrolytes are more stable under simulated physiological conditions, those shorter have higher activity. Tailoring degree ratio components been able identify formulation shows sustained inhibitory growth P. aeruginosa can reduce number viable colonies pathogen over 10,000 times effectively than our previously reported formulation.
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