Advances in Drug Delivery Strategies for Microbial Healthcare Products
作者： Jose Manuel Ageitos , Marcos Garcia-Fuentes
DOI: 10.1007/978-3-030-01881-8_1
关键词:
摘要: Biomacromolecules produced by microorganisms have been employed in healthcare ever since ancient times as part of fermented products or natural remedies, but from the discovery penicillin 1928 Alexander Fleming, it is impossible to conceive medicine without microbial products. In addition antibiotics, produce secondary metabolites currently anti-inflammatory, immunosuppressant, and antitumoral drugs, among others. As with any other well-established undesirable side effects may occur these compounds due excessive systemic drug concentrations, their pharmacological activity can be lost development resistance target cells. Besides, many drugs intrinsic physicochemical properties that limit application such low aqueous solubility, bioavailability, acute toxicity, fast pre-systemic degradation.
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