Role of matrix metalloproteinases and their inhibitors in tumor invasion and metastasis
作者： P. Z. Khasigov , O. V. Podobed , T. S. Gracheva , K. D. Salbiev , S. V. Grachev
关键词: Metastasis 、 Malignant Growth 、 Cancer research 、 Tumor progression 、 Dual role 、 Enzyme 、 Gelatinases 、 Chemistry 、 Matrilysin 、 Matrix metalloproteinase
摘要: The role of various matrix metalloproteinases (MMP)—such as gelatinases, stromelysins, matrilysin, collagenase-3, and membrane-bound MMP (MB-MMP)—in tumor invasion metastasis is discussed. Data suggesting significance for malignant growth the expression level these enzymes also their activators inhibitors are presented. It concluded that at different stages progression activity MMPs displayed, which regulated by factors oncogenes. Different malignancies characterized changes in activities specific MMPs. presented show ratio between tissue (TIMP) metastasis, especially connection with a dual TIMP both activators.
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