Silent cerebral infarction predicts vascular events in hemodialysis patients.
作者： Toshihide Naganuma , Junji Uchida , Kenji Tsuchida , Yoshiaki Takemoto , Shinji Tatsumi
DOI: 10.1111/J.1523-1755.2005.00351.X
关键词: Internal medicine 、 Stroke 、 Prospective cohort study 、 Hazard ratio 、 Proportional hazards model 、 Surgery 、 Vascular disease 、 Cerebral infarction 、 Cardiology 、 Hemodialysis 、 Medicine 、 Cause of death
摘要: Silent cerebral infarction predicts vascular events in hemodialysis patients. Background Cardiovascular disease is the leading cause of death (HD) We have previously reported a higher incidence silent (SCI) HD patients compared with control group using MRI studies. In present study, we examined whether or not SCI could predict Methods Cranial magnetic resonance imaging (MRI) was performed on 119 without symptomatic cerebrovascular disease. detected by MRI, and were prospectively followed up. The end points study major related to (cerebral events, cardiac sudden deaths). investigated prognostic role cerebral, cardiac, Kaplan-Meier method Cox proportional hazards analysis. Results prevalence 49.6% During follow-up period maximum 60 months, which included 13 5 3 deaths, occurred 21 presence predictive for morbidity absence [18.6% ( N = 11) vs. 3.3% 2), P 0.0169, 30.5% 18) 5.0% 3), 0.0006, respectively]. By multivariate analysis, remained powerful independent predictor (hazard ratio 7.33, 95% CI 1.27–42.25: 4.48, 1.09–18.41). Conclusion findings indicate that new risk factor
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