Helicobacter pylori and Gastric Cancer: A New Paradigm For Inflammation-Associated Epithelial Cancers

摘要: Although gastric cancer has been investigated for centuries, the association with Helicobacter pylori infection recognized only past few decades. disease declining in most industrialized countries, it remains second common cause of death worldwide and is, theory, a largely preventable disease. We have gained many new insights advances from studies Helicobacter-infected mouse models. These models corroborate findings human patients, whom outcome is determined by expression host proinflammatory cytokines. Studies cellular origins model led to surprising insight that may originate circulating bone marrow-derived stem cells (BMDC) not resident tissue as previously believed. It likely this BMDC paradigm epithelial will prove useful future investigations gastrointestinal metaplasia cancers associated chronic inflammation.