A New NOE-mediated MT Signal at Around -1.6ppm for Detecting Ischemic Stroke in Rat Brain
作者： Xiao-Yong Zhang , Feng Wang , Aqeela Afzal , Junzhong Xu , John C Gore
DOI: 10.1016/J.MRI.2016.05.002
关键词: Stroke 、 Lesion 、 Rat brain 、 Magnetic resonance imaging 、 Effective diffusion coefficient 、 Chemistry 、 Signal 、 Nuclear magnetic resonance 、 In vivo 、 Magnetization transfer
摘要: In the present work, we reported a new nuclear Overhauser enhancement (NOE)-mediated magnetization transfer (MT) signal at around -1.6ppm (NOE(-1.6)) in rat brain and investigated its application detection of acute ischemic stroke rodent model. Using continuous wave (CW) MT sequence, NOE(-1.6) is reliably detected brain. The amplitude this NOE was quantified using 5-pool Lorentzian Z-spectral fitting method. Amplitudes amide, amine, -3.5ppm (NOE(-3.5)), as well were mapped method Several other conventional imaging parameters (R1, R2, apparent diffusion coefficient (ADC), semi-solid pool size ratio (PSR)) also measured. Our results show that NOE(-1.6), R1, ADC, APT signals from lesion have significant changes 0.5-1h after stroke. Compared with several parameters, shows strongest contrast differences between contralateral normal tissues stays consistent over time until 2h onset demonstrate potential for assessment vivo might provide broad applications abnormal tissues.
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