Establishment and characterization of pheochromocytoma tumor models expressing different levels of trkA receptors.
作者： Itzhak Katzir , Jashovam Shani , Dalia Shabashov , Judith Dagan , Philip Lazarovici
DOI: 10.1016/S0304-3835(03)00414-2
关键词: Low-affinity nerve growth factor receptor 、 In vivo 、 Internal medicine 、 Receptor 、 Pheochromocytoma 、 Cell culture 、 Tropomyosin receptor kinase A 、 Enolase 、 Cancer research 、 Nerve growth factor 、 Endocrinology 、 Biology
摘要: To date experimental in vivo pheochromocytoma (PC) models have not been available. A major vitro PC model consists of PC12 cells that respond to nerve growth factor (NGF) by differentiation, mediated the trkA receptor. We report establishment tumor expressing low and high levels receptor CD1 nude mice. The tumors are characterized their responsiveness NGF, karyotype, presence enolase, chromaffin granules, as well dopamine release. These novel facilitate research on role cancer development trkA-selective anti-cancer agents.
elsevier.com
sci-hub.se 参考文章(40)
Roland H. Goldbrunner, Sven Wagner, Klaus Roosen, Joerg-Christian Tonn, Models for assessment of angiogenesis in gliomas. Journal of Neuro-oncology. ,vol. 50, pp. 53- 62 ,(2000) , 10.1023/A:1006462504447
Blesch A, Tuszynski M, Ex vivo gene therapy for Alzheimer's disease and spinal cord injury Clinical neuroscience (New York, N.Y.). ,vol. 3, pp. 268- 274 ,(1995)
B. A. J. Ponder, G. Wirnsberger, I. Rinner, S. Porta, T. Henn, B. Niederle, R. Pfragner, A. Behmel, D. P. Smith, First continuous human pheochromocytoma cell line: KNA. Biological, cytogenetic and molecular characterization of KNA cells. Journal of Neurocytology. ,vol. 27, pp. 175- 186 ,(1998) , 10.1023/A:1006959625068
Andreas Zielke, Robert S. Bresalier, Allan E. Siperstein, Orlo H. Clark, Matthias Rothmund, Quan-Yang Duh, A unique allogenic model of metastatic pheochromocytoma: PC12 rat pheochromocytoma xenografts to nude mice and establishment of metastases-derived PC12 variants Clinical & Experimental Metastasis. ,vol. 16, pp. 341- 352 ,(1998) , 10.1023/A:1006565530421
B. H Czepulkowski, D. E Rooney, Human cytogenetics : a practical approach IRL Press. ,(1986)
Hubert Hondermarck, Louis Hornez, Françoise Révillion, Simon Descamps, Bénoni Boilly, Jean-Philippe Peyrat, Valérie Pawlowski, Mohamed Hebbar, Expression of nerve growth factor receptors and their prognostic value in human breast cancer. Cancer Research. ,vol. 61, pp. 4337- 4340 ,(2001)
Moses Chao, Patrizia Casaccia-Bonnefil, Bruce Carter, Alexandra Chittka, Haeyoung Kong, Sung Ok Yoon, Neurotrophin receptors: mediators of life and death. Brain Research Reviews. ,vol. 26, pp. 295- 301 ,(1998) , 10.1016/S0165-0173(97)00036-2
H. Koizumi, E. Shibayama, Cellular localization of the Trk neurotrophin receptor family in human non-neuronal tissues. American Journal of Pathology. ,vol. 148, pp. 1807- 1818 ,(1996)
Peter I. Lelkes, Esther Shohami, Eugenia Bloch-Shilderman, Philip Lazarovici, Victoria Trembovler, Saleh Abu-Raya, Yehuda Gutman, Characterization of Pardaxin-Induced Dopamine Release from Pheochromocytoma Cells: Role of Calcium and Eicosanoids Journal of Pharmacology and Experimental Therapeutics. ,vol. 288, pp. 399- 406 ,(1999)
Barbara L. Hempstead, Stuart J. Rabin, Leni Kaplan, Susan Reid, Luis F. Parada, David R. Kaplant, Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiation. Neuron. ,vol. 9, pp. 883- 896 ,(1992) , 10.1016/0896-6273(92)90241-5