Biosynthesis and processing of the somatostatin family of peptide hormones
作者： P. C. Andrews , J. E. Dixon
DOI: 10.3109/00365528609087428
关键词: Somatostatin 、 Gene 、 Biology 、 Catfish 、 Somatostatin receptor 2 、 Somatostatin receptor 1 、 Complementary DNA 、 Intron 、 Biochemistry 、 Molecular biology 、 Somatostatin receptor 3
摘要: Andrews PC, Dixon JE. Biosynthesis and processing of the somatostatin family peptide hormones.Understanding biosynthesis hormones has greatly increased in recent years. Isolation sequencing rat gene indicates that it contains a single intron located between codons for Gn(-57) Glu(-56) preprosomatostatin. The three repetitive sequences, one at 5′ end two them 3′ to coding portion. Two sequences consist alternating purine-pyrimidine bases have been shown adopt Z-DNA structures vitro. cDNA codes 116-residue structurally similar anglerfish catfish precursors 14-residue (SST-14). In addition SST-14, both contain an additional pancreatic somatostatin, each derived from different gene. 22-residue which is O-glycosylated Thr-5. ...
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