Prostate Cancers Scored as Gleason 6 on Prostate Biopsy are Frequently Gleason 7 Tumors at Radical Prostatectomy: Implication on Outcome

作者: Jehonathan H. Pinthus , Maciej Witkos , N.E. Fleshner , Joan Sweet , Andrew Evans

DOI: 10.1016/J.JURO.2006.04.102

关键词: Gleason Score 6BiopsyGrading (tumors)ProstateProstate-specific antigenUrologyMedicineProstate biopsyProstate cancerProstatectomy

摘要: Purpose: Differentiation between Gleason score 6 and 7 in prostate biopsy is important for treatment decision making. Nevertheless, under grading errors compared with the actual pathological grade at radical prostatectomy are common. We characteristics outcomes of tumors that were scored on but subsequent evaluation to those a consistent rating or surgery.Materials Methods: performed retrospective database analysis from our referral center (1989 2004). pre-prostatectomy characteristics, features post-radical specific antigen failure rate, defined as any 2 consecutive detectable measurements, 3 subgroups patients, including 156 matched prostatectomy, 205 upgraded 6/7, ...

参考文章(22)
Tracy M. Downs, Gary D. Grossfeld, Katsuto Shinohara, Peter R. Carroll, Transrectal Ultrasound-Guided Prostate Biopsy Humana Press, Totowa, NJ. pp. 3- 33 ,(2003) , 10.1007/978-1-59259-422-1_1
Subir Nag, David Beyer, Jay Friedland, Peter Grimm, Ravinder Nath, None, American brachytherapy society (ABS) recommendations for transperineal permanent brachytherapy of prostate cancer International Journal of Radiation Oncology Biology Physics. ,vol. 44, pp. 789- 799 ,(1999) , 10.1016/S0360-3016(99)00069-3
Christopher R. King, John P. Long, Prostate biopsy grading errors: a sampling problem? International Journal of Cancer. ,vol. 90, pp. 326- 330 ,(2000) , 10.1002/1097-0215(20001220)90:6<326::AID-IJC3>3.0.CO;2-J
PAUL D. SVED, PABLO GOMEZ, M. MANOHARAN, SANDY S. KIM, MARK S. SOLOWAY, LIMITATIONS OF BIOPSY GLEASON GRADE: IMPLICATIONS FOR COUNSELING PATIENTS WITH BIOPSY GLEASON SCORE 6 PROSTATE CANCER The Journal of Urology. ,vol. 172, pp. 98- 102 ,(2004) , 10.1097/01.JU.0000132135.18093.D6
Grant D Carlson, Christina B Calvanese, Hillel Kahane, Jonathan I Epstein, Accuracy of Biopsy Gleason Scores from a Large Uropathology Laboratory: Use of a Diagnostic Protocol to Minimize Observer Variability Urology. ,vol. 51, pp. 525- 529 ,(1998) , 10.1016/S0090-4295(98)00002-8
Takashi Fukagai, Thomas Namiki, Hideo Namiki, Robert G. Carlile, Makoto Shimada, Hideki Yoshida, Discrepancies between Gleason scores of needle biopsy and radical prostatectomy specimens Pathology International. ,vol. 51, pp. 364- 370 ,(2001) , 10.1046/J.1440-1827.2001.01207.X
H. BALLENTINE CARTER, PATRICK C. WALSH, PATRICIA LANDIS, JONATHAN I. EPSTEIN, Expectant management of nonpalpable prostate cancer with curative intent: Preliminary results The Journal of Urology. ,vol. 167, pp. 1231- 1234 ,(2002) , 10.1016/S0022-5347(05)65271-8