Voxelwise meta-analysis of gray matter abnormalities in dementia with Lewy bodies

摘要: Abstract Background Increasing neuroimaging studies have revealed brain gray matter (GM) atrophy by voxel-based morphometry (VBM) in patients with dementia Lewy bodies (DLB) relative to healthy controls. However, the spatial localization of GM abnormalities reported existing is heterogeneous. Here, we aimed investigate concurrence across VBM help clarify structural underpinning this condition. Methods A systematic search for DLB and controls published PubMed database from January 2000 March 2014 was conducted. quantitative meta-analysis whole-brain performed means Anisotropic Effect Size version Signed Differential Mapping (AES-SDM) software package. Results Seven comprising 218 219 were included present study. Compared subjects, group showed consistent decreased right lateral temporal/insular cortex left lenticular nucleus/insular cortex. The results remained largely unchanged following jackknife sensitivity analyses. Meta-regression analysis indicated an increased probability finding superior temporal gyrus lower MMSE scores. Conclusions quantitatively demonstrates a characteristic pattern alternations that contributed understanding pathophysiology underlying DLB. Future will benefit employing meta-analytical comparisons other subtypes solid evidence extend these findings.