Cure of peptic gastric ulcer associated with eradication of Helicobacter pylori. Finnish Gastric Ulcer Study Group.
作者： K Seppala , P Pikkarainen , P Sipponen , E Kivilaakso , M H Gormsen
DOI: 10.1136/GUT.36.6.834
关键词: Metronidazole 、 Anti-ulcer Agent 、 Amoxicillin 、 Internal medicine 、 Helicobacter pylori 、 Stomach 、 Spirillaceae 、 Gastroenterology 、 Antibacterial agent 、 Ranitidine 、 Medicine
摘要: The effect of Helicobacter pylori eradication on ulcer healing and the relapse rate were investigated in a multicentre trial 239 gastric patients. Patients with H positive randomly assigned to one three groups: (A) 10 days' treatment metronidazole eight weeks' colloidal bismuth subcitrate (CBS) (84 patients); (B) placebo weeks CBS (73 or (C) ranitidine (82 patients). At 12 210 patients, was present (9%) 35 negative 45 (26%) 175 patients (p < 0.05). Results after year follow up available for 205 Between 52 weeks, two (7%) relapses occurred 29 60 (47%) 128 0.001). After open triple therapy (CBS 120 mg four times daily, amoxicillin 500 400 daily), given relapse, only (an NSAID user) 55 successfully treated had an during up. Healing is rapid recurrence infrequent successful eradication. changes natural history disease.
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