Genetically determined differences in the response of alpha 1 -antitrypsin levels in human serum to typhoid vaccine
作者： Friedrich Kueppers
DOI: 10.1007/BF00291864
关键词: Gene 、 Heterozygote advantage 、 Immunology 、 Common gene 、 Typhoid vaccine 、 Biology 、 Blood protein electrophoresis 、 Endocrinology 、 Molecular medicine 、 Internal medicine
摘要: Normal individuals and those homozygous heterozygous for the gene which determines deficiency in serum α1-antitrypsin (α1-at) were given an intravenous injection of typhoid vaccine. Following this trypsin-inhibiting capacity concentration α1-at increases markedly normal individuals. Heterozygotes have elevation their but reach only 50 percent levels reached by homozygotes common (normal individuals). Their values are however temporarily range men not Homozygotes show a small under these conditions. These findings demonstrate that (1) increase after vaccine is largely due to concentration, (2) inhibits quantitative response such stimulus.
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