Human neutrophil peptides 1, 2 and 3 are biochemical markers for metastatic colorectal cancer.
作者： Jakob Albrethsen , Christian H. Møller , Jesper Olsen , Hans Raskov , Steen Gammeltoft
DOI: 10.1016/J.EJCA.2006.05.039
关键词: Metastasis 、 Neutrophile 、 Biochemical markers 、 Granulocyte 、 Gastroenterology 、 Colorectal cancer 、 Internal medicine 、 Pathology 、 Human neutrophil 、 Medicine 、 Stage (cooking) 、 Chemotherapy
摘要: Colorectal cancer (CRC) patients have increased levels of human neutrophil peptides 1-3 (HNP1-3) in tumour tissue and plasma. The aim is to study whether the amount HNP1-3 plasma from CRC correlate with Dukes' stages A-D. tissue, normal colonic mucosa, was determined mass spectrometry. Plasma were enzyme-linked immuno-sorbent assay (ELISA). spectrometry tumours compared stage A-D, whereas only elevated D healthy individuals. concentration ELISA C D, but not A B. It concluded that a potential marker for prognostic assessment, surveillance patients, monitoring chemotherapy advanced disease.
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