Immunohistochemical staining of human alpha-defensin-1 (HNP-1), in the submandibular glands of patients with oral carcinomas.

摘要: The purpose of this study was the immunohistochemical localization and distribution HNP-1 in submandibular glands patients with oral carcinomas. Tissue sections were embedded paraffin, immunostained by streptavidin-biotin coupled peroxidase method. Striated duct cells stained anti-defensin antibody. Neutrophils capillary intimal also stained. Defensins (HNPs) are peptides that occur neutrophils protect against bacteria tumor cells. Human alpha-defensin-1 (HNP-1) is such a peptide, possessing both antimicrobial cytotoxic activities. presence striated cancer patients, suggests likely role immunity, for peptide.