Inhibition of p38 Mitogen-Activated Protein Kinase Decreases Cardiomyocyte Apoptosis and Improves Cardiac Function After Myocardial Ischemia and Reperfusion

作者: Xin L. Ma , Sanjay Kumar , Feng Gao , Calvert S. Louden , Bernard L. Lopez

DOI: 10.1161/01.CIR.99.13.1685

关键词: MAPK/ERK pathwayNecrosisCardiac function curveApoptosisIschemiaProtein kinase AMedicineInternal medicineSB 203580Endocrinologyp38 mitogen-activated protein kinases

摘要: … that myocardial ischemia and reperfusion, a … myocardial apoptosis after ischemia and reperfusion. Most interestingly, we have found that inhibiting p38 MAPK, which reduces myocardial …

参考文章(24)
S.-M. Hsu, L. S. Hailey, Su Su Xie, R. H. Bardales, R. F. Schaefer, In situ apoptosis assay for the detection of early acute myocardial infarction. American Journal of Pathology. ,vol. 149, pp. 821- 829 ,(1996)
Dharminder Chauhan, Surender Kharbanda, Atsushi Ogata, Mitsuyoshi Urashima, Gerrard Teoh, Michael Robertson, Donald W. Kufe, Kenneth C. Anderson, Interleukin-6 Inhibits Fas-Induced Apoptosis and Stress-Activated Protein Kinase Activation in Multiple Myeloma Cells Blood. ,vol. 89, pp. 227- 234 ,(1997) , 10.1182/BLOOD.V89.1.227
P. Anversa, J. Kajstura, G. Olivetti, Wei Cheng, S. Krajewski, K. Reiss, J. C. Reed, E. H. Sonnenblick, W. A. Clark, Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats. Laboratory Investigation. ,vol. 74, pp. 86- 107 ,(1996)
C M Pombo, J V Bonventre, J Avruch, J R Woodgett, J M Kyriakis, T Force, The stress-activated protein kinases are major c-Jun amino-terminal kinases activated by ischemia and reperfusion. Journal of Biological Chemistry. ,vol. 269, pp. 26546- 26551 ,(1994) , 10.1016/S0021-9258(18)47229-8
Birgit Brenner, Ursula Koppenhoefer, Christoph Weinstock, Otwin Linderkamp, Florian Lang, Erich Gulbins, Fas- or Ceramide-induced Apoptosis Is Mediated by a Rac1-regulated Activation of Jun N-terminal Kinase/p38 Kinases and GADD153 Journal of Biological Chemistry. ,vol. 272, pp. 22173- 22181 ,(1997) , 10.1074/JBC.272.35.22173
John P Veinot, Deborah A Gattinger, Henry Fliss, Early apoptosis in human myocardial infarcts. Human Pathology. ,vol. 28, pp. 485- 492 ,(1997) , 10.1016/S0046-8177(97)90039-3
Xin L Ma, Bernard L Lopez, Gao-Lin Liu, Theodore A Christopher, Harry Ischiropoulos, Peroxynitrite aggravates myocardial reperfusion injury in the isolated perfused rat heart Cardiovascular Research. ,vol. 36, pp. 195- 204 ,(1997) , 10.1016/S0008-6363(97)00179-X
Antti Saraste, Kari Pulkki, Markku Kallajoki, Kenth Henriksen, Martti Parvinen, Liisa-Maria Voipio-Pulkki, Apoptosis in Human Acute Myocardial Infarction Circulation. ,vol. 95, pp. 320- 323 ,(1997) , 10.1161/01.CIR.95.2.320
Z. Xia, M. Dickens, J. l Raingeaud, R. J. Davis, M. E. Greenberg, Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis Science. ,vol. 270, pp. 1326- 1331 ,(1995) , 10.1126/SCIENCE.270.5240.1326
Tinggui Yin, Gulzar Sandhu, Curt D Wolfgang, Althea Burrier, Randy L Webb, Dean F Rigel, Tsonwin Hai, James Whelan, None, Tissue-specific Pattern of Stress Kinase Activation in Ischemic/Reperfused Heart and Kidney Journal of Biological Chemistry. ,vol. 272, pp. 19943- 19950 ,(1997) , 10.1074/JBC.272.32.19943