Analysis of the induction of alkali sensitive sites in the DNA by chromate and other agents that induce single strand breaks

摘要: CaCrO4 was shown to induce alkali labile sites in the DNA of Chinese hamster ovary cells by analysis lack linearity alkaline elution curves, and a study dependence upon pH from filters. The effect on these parameters compared with N-methyl-N-nitrosourea, an agent known produce sites. Based aforementioned HgCl2, formaldehyde X-rays caused formation frank single strand breaks little or no induction These findings demonstrate differences production sensitive agents that cause breaks.