Chapter 1 Genotoxicity of Chromate
作者： James J. Covino , Kent D. Sugden
DOI: 10.1016/S1872-0854(07)02001-2
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摘要: Publisher Summary This chapter deals with current progress on the understanding of interaction chromium DNA and should help to elucidate mechanism chromate-induced genotoxicity. The hexavalent oxidation state chromium, chromate or Cr (VI), is established as a human respiratory carcinogen based more than century's worth epidemiological medical evidence. Over years, research has illustrated chromate's myriad mutagenic, genotoxic, carcinogenic effects in wide range vitro , cellular, whole animal model systems. toxic soluble (VI) are direct consequence its aqueous geometry, charge, redox properties at physiological pH. end product intracellular metabolism octahedral, +3 state, (III). (III) complexes certain ligands toxic, clastogenicbut risk this humans considered inconclusive by Agency for Toxic Substances Disease Registry (ATSDR) International Research Cancer (IARC). In addition, competing such phosphate buffer ethylenediaminetetraacetic acid (EDTA) shown block ascorbate-mediated Cr-DNA interactions reverse vast majority mutations providing insight transient dynamics adduct their potential
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