Synthesis and antitumor activity of (4-hydroxyphenyl)[5-substituted alkyl/aryl)-2-thioxo-1,3,4-thiadiazol-3-yl]methanone and [(3,4-disubstituted)-1,3-thiazol-2ylidene]-4-hydroxybenzohydrazide
作者： Ritesh P. Bhole , Kishore P. Bhusari
DOI: 10.1007/S00044-010-9371-9
关键词: Thiazoline 、 Aryl 、 Pharmacology toxicology 、 Chemistry 、 Alkyl 、 Cancer cell lines 、 Antitumor activity 、 Cancer 、 Stereochemistry
摘要: To examine new drug leads with potential anticancer activity, some (4-hydroxyphenyl)[5-substituted alkyl/aryl)-2-thioxo-1,3,4-thiadiazol-3-yl]methanone (4.a–4.c) and [-(3,4-disubstituted)-1,3-thiazol-2ylidene)]-4-hydroxybenzohydrazide (6.a–6.d) were synthesized using appropriate synthetic route. The newly prepared compounds 4.a–4.c 6.a–6.d demonstrated inhibitory effects on the growth of a wide range cancer cell lines especially leukemia (HL-60), non-small lung (HOP-92), renal (ACHN) at GI50 −4.23 to −7.23.
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