Cerebral Blood Flow Modulation by Basal Forebrain or Whisker Stimulation Can Occur Independently of Large Cytosolic Ca2+ Signaling in Astrocytes
作者： Norio Takata , Terumi Nagai , Katsuya Ozawa , Yuki Oe , Katsuhiko Mikoshiba
DOI: 10.1371/JOURNAL.PONE.0066525
关键词: Cerebral cortex 、 Somatosensory system 、 Internal medicine 、 Muscarinic acetylcholine receptor 、 Cerebral blood flow 、 Nucleus basalis 、 Stimulation 、 Basal forebrain 、 Anatomy 、 Cholinergic 、 Endocrinology 、 General Biochemistry, Genetics and Molecular Biology 、 General Agricultural and Biological Sciences 、 General Medicine
摘要: We report that a brief electrical stimulation of the nucleus basalis Meynert (NBM), primary source cholinergic projection to cerebral cortex, induces biphasic cortical blood flow (CBF) response in somatosensory cortex C57BL/6J mice. This CBF response, measured by laser Doppler flowmetry, was attenuated muscarinic type acetylcholine receptor antagonist atropine, suggesting possible involvement astrocytes this modulation. However, we find IP3R2 knockout mice, which lack cytosolic Ca2+ surges astrocytes, show similar changes. Moreover, whisker resulted degrees increase mice and background strain C57BL/6J. Our results neural activity-driven modulation could occur without large increases astrocytes.
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