Genomic profiling of prostate cancers from African American men.

摘要: African American (AA) men have a higher incidence and significantly mortality rates from prostate cancer than white men, but the biological basis for these differences are poorly understood. Few studies been carried out to determine whether there areas of allelic loss or gain in cancers AA that overrepresented specific this group. To better understand molecular mechanisms we analyzed 20 with high-density single-nucleotide polymorphism arrays detect genomic copy number alterations. We identified 17 regions showing significant 4 gains. Most had linked by previous alterations predominantly patients.We novel region at 4p16.3, which has shown be lost breast, colon, bladder cancers. Comparison our primary tumors patients previously published cohort similar pathological characteristics showed frequency numerous loci including 6q13-22, 8p21, 13q13-14, 16q11-24 gains 7p21 8q24, all frequencies metastatic lesions cohort. Thus, clinically localized more closely resembled men. This difference may part explain aggressive clinical behavior