TACC3 Is Essential for EGF-Mediated EMT in Cervical Cancer
作者： Geun-Hyoung Ha , Jung-Lye Kim , Eun-Kyoung Yim Breuer
DOI: 10.1371/JOURNAL.PONE.0070353
关键词:
摘要: The third member of transforming acidic coiled-coil protein (TACC) family, TACC3, has been shown to be an important player in the regulation centrosome/microtubule dynamics during mitosis and found deregulated a variety human malignancies. Our previous studies have suggested that TACC3 may involved cervical cancer progression chemoresistance, its overexpression can induce epithelial-mesenchymal transition (EMT) by activating phosphatidylinositol 3-kinase (PI3K)/Akt extracellular signal-regulated kinases (ERKs) signal transduction pathways. However, upstream mechanisms TACC3-mediated EMT functional/clinical importance remain elusive. Epidermal growth factor (EGF) potent inducer associated with tumor invasion metastasis. In this study, we is overexpressed induced upon EGF stimulation. induction dependent on tyrosine kinase activity receptor (EGFR). Intriguingly, depletion abolishes EGF-mediated EMT, suggesting required for EGF/EGFR-driven process. Moreover, Snail, key correlated expression cancer. Collectively, our study highlights novel function process suggests targeting attractive strategy treat cancers driven EGF/EGFR signaling
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