The effect of various chemotherapeutic agents given with mild hyperthermia on different types of tumours.

摘要: It has been shown that hyperthermia can enhance the cytotoxicity of some chemotherapeutics. However, most effective agent(s) at elevated temperatures have yet to be determined. A previous study suggests drug choice may different from physiological temperature, and alkylating agents temperatures. To further investigate these possibilities, effect chemotherapeutic were compared. These cyclophosphamide, ifosfamide, melphalan, cis-diamminedichloroplatinum (II), 5-fluorouracil, mitomycin C bleomycin. Three tumours (mammary carcinoma, osteosarcoma squamous cell carcinoma) used. They transplanted into feet C3H/He mice. When reached 65 mm(3), a test agent was injected intraperitoneally. Tumours immediately heated 41.5 degrees for 30 min, tumour growth (TG) time studied each tumour. Using TG times, TG-50 (the required one-half total number treated reach volume 800 mm(3) mm(3)) calculated. Subsequently, delay (GDT) thermal enhancement ratio (TER) obtained. The GDT difference between non-treated control tumours. TER group with an room temperature. Results showed top three tested solely agents--CY, IFO L-PAM--for kind cisplatin smaller than those agents. smallest TER, 1.1, observed which given mammary C, carcinoma. could concluded might drugs many types possible mechanisms associated are discussed.