[44] Rat apolipoprotein A-IV: Application of computational methods for studying the structure, function, and evolution of a protein☆

作者: Mark S. Boguski , Nabil A. Elshourbagy , John M. Taylor , Jeffrey I. Gordon

DOI: 10.1016/0076-6879(86)28104-5

关键词: Intergenic regionNucleic acidComputational biologyGeneticsRepeated sequencePseudogeneApolipoprotein A-IVBiologyChylomicronStructural similarityGene

摘要: Publisher Summary ApoA-IV is one of the major protein components rat chylomicrons and HDL also associated with in humans dogs; however, precise metabolic function this remains obscure. This chapter presents a computer program appropriate to study nucleic acid sequences, critical interpretation results that can lead specific experimentally testable predictions protein's structure function, may yield insights into its evolution location gene. The demonstrates apoA-IV bears striking structural similarity human apoA-I. Statistical analyses homologies between apolipoproteins A-I, A-IV, E show all three sequences diverged from common ancestral Assuming genes for these proteins had evolved as result series intra- intergenic unequal cross-overs, it likely their genetic loci were at time linked. Given fact, existence other or pseudogenes based upon repeated sequence motif distinct possibility.

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