The complement system and host defense against Pseudomonas endophthalmitis.

摘要: The authors examined the role of complement system in host defense against Pseudomonas aeruginosa endophthalmitis. Guinea pigs received intravitreal injections P. aeruginosa, and comparisons were made between bacterial counts from vitreous control guinea experimental that underwent systemic decomplementation with cobra venom factor. In group 1 (intravitreal injection 42 organisms), significantly higher decomplemented versus at days 1, 2, 3 after but not day 7 when levels returned to normal. 2 102 only no statistically significant differences thereafter. 150 bacteria), there pigs. Our results suggest partially show impaired this is restored as return Intravitreal numbers a overwhelms obscures any beneficial effect on defense.