Complement system and host defense against staphylococcal endophthalmitis.

摘要: PURPOSE: The authors studied the role of complement system in host defense against Staphylococcus epidermidis and S. aureus endophthalmitis. METHODS: Guinea pigs model received an intravitreal injection 7000 viable organisms, guinea 50 organisms. experimental animals each were decomplemented with intraperitoneal (IP) injections cobra venom factor, whereas control IP normal saline. Mean log bacterial counts vitreous mean serum titers compared on days 1, 2, 3, 7. RESULTS: In model, significantly higher group than 1 2 (P < 0.01) day 3 0.05). lower at all 0.01). 0.05) 0.01), but not CONCLUSION: These results suggest that show impaired to endophthalmitis this is restored as levels approach normal.