Review of Emerging Treatments for Age-Related Macular Degeneration

摘要: In the era of pathway-based therapy, all treatments for AMD will address some step in pathway that leads from early to late AMD. Steps pathogenesis appear be good targets drug development include following: (1) oxidative damage, (2) lipofuscin accumulation, (3) chronic inflammation, (4) mutations complement pathway, (5) mitochondrial (6) Alu RNA accumulation RPE, and (7) BMP-4 RPE. neovascularization can targeted combination therapy angiogenic factor production, extracellular release, binding factors receptors (and activation intracellular signaling after receptor binding), endothelial cell basement membrane degradation), proliferation, directed migration, matrix remodeling, (8) tube formation, (9) vascular stabilization. Combination likely supplant monotherapy as treatment choice because clinical benefits superior preventing complications