Peripheral 5-HT7 receptors as a new target for prevention of lung injury and mortality in septic rats.
作者： Elif Cadirci , Zekai Halici , Yasin Bayir , Abdulmecit Albayrak , Emre Karakus
DOI: 10.1016/J.IMBIO.2013.04.012
关键词: Systemic inflammatory response syndrome 、 Receptor 、 Inflammation 、 Multiple organ dysfunction syndrome 、 Lung injury 、 Sepsis 、 Agonist 、 Immunology 、 Medicine 、 Receptor expression
摘要: Abstract Sepsis is a complex pathophysiological event involving metabolic acidosis, systemic inflammatory response syndrome, tissue damage and multiple organ dysfunction syndrome. Although many new mechanisms are being investigated to enlighten the pathophysiology of sepsis, there no effective treatment protocol yet. Presence 5-HT7 receptors in immune tissues prompted us hypothesize that these have roles inflammation sepsis. We effects receptor agonists antagonists on serum cytokine levels, lung oxidative stress, histopathology, nuclear factor κB (NF-κB) positivity density cecal ligation puncture (CLP) induced sepsis model rats. Agonist administration septic rats increased survival time; decreased against CLP; stress antioxidant system lungs; NF-κB immunopositivity, which high rats; sepsis-induced injury. In rats, as result response, expression lungs significantly agonist administration, related mortality, expression. conclusion, all data suggest stimulation may be therapeutic target for prevention impaired injury mortality.
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