Multicompartment kinetic models for lead. II. Linear kinetics and variable absorption in humans without excessive lead exposures.
作者： Allan H. Marcus
DOI: 10.1016/0013-9351(85)90038-6
关键词: Intestinal absorption 、 Biochemistry 、 Chemistry 、 Kinetic model 、 Lead exposure 、 Linear kinetics 、 Endocrinology 、 Biological materials 、 Absorption (skin) 、 Internal medicine 、 Lead (electronics) 、 Trabecular bone
摘要: Multicompartment models with constant fractional transfer rates have been fitted to experimental data on lead metabolism in four subjects studied by M. B. Rabinowitz, G. W. Wetherill, and J. D. Kopple (Science 182, 725-727, 1973; Environ. Health Perspect. 7, 145-153, 1974; Arch. 31, 220-223, 1976; Clin. Invest. 58, 260-270, Lab. Med. 90, 238-248, 1977). Long-term retention is estimated for blood, soft tissue, cortical trabecular bone pools, facial hair. The absorption of from diet shown change time, but no evidence was found other variable or nonlinear kinetic mechanisms humans without excessive exposure.
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