Phosphorylation of Sox2 Cooperates in Reprogramming to Pluripotent Stem Cells

作者: Chul-Ho Jeong , Yong-Yeon Cho , Myoung-Ok Kim , Sung-Hyun Kim , Eun-Jin Cho

DOI: 10.1002/STEM.540

关键词: SOX2PhosphorylationReprogrammingCell biologyKLF4Cancer researchInduced pluripotent stem cellBiologyProtein kinase BEmbryonic stem cellSomatic cell

摘要: … of Sox2 in response to LIF using a phospho-Sox2 (… /Sox2)-induced iPS experiment, OS (wt) MEFs demonstrated significantly more potency in increasing the number of AP-positive iPS …

参考文章(33)
T. Wakayama, A. C. F. Perry, M. Zuccotti, K. R. Johnson, R. Yanagimachi, Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei Nature. ,vol. 394, pp. 369- 374 ,(1998) , 10.1038/28615
Toshinobu Nakamura, Kimiko Inoue, Shoko Ogawa, Hiroki Umehara, Narumi Ogonuki, Hiromi Miki, Tohru Kimura, Atsuo Ogura, Toru Nakano, Effects of Akt signaling on nuclear reprogramming. Genes to Cells. ,vol. 13, pp. 1269- 1277 ,(2008) , 10.1111/J.1365-2443.2008.01243.X
Shinji Masui, Yuhki Nakatake, Yayoi Toyooka, Daisuke Shimosato, Rika Yagi, Kazue Takahashi, Hitoshi Okochi, Akihiko Okuda, Ryo Matoba, Alexei A. Sharov, Minoru S. H. Ko, Hitoshi Niwa, Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells Nature Cell Biology. ,vol. 9, pp. 625- 635 ,(2007) , 10.1038/NCB1589
Masato Nakagawa, Michiyo Koyanagi, Koji Tanabe, Kazutoshi Takahashi, Tomoko Ichisaka, Takashi Aoi, Keisuke Okita, Yuji Mochiduki, Nanako Takizawa, Shinya Yamanaka, Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts Nature Biotechnology. ,vol. 26, pp. 101- 106 ,(2008) , 10.1038/NBT1374
Bo Feng, Jia-Hui Ng, Jian-Chien Dominic Heng, Huck-Hui Ng, Molecules that Promote or Enhance Reprogramming of Somatic Cells to Induced Pluripotent Stem Cells Cell Stem Cell. ,vol. 4, pp. 301- 312 ,(2009) , 10.1016/J.STEM.2009.03.005
Trond Aasen, Angel Raya, Maria J Barrero, Elena Garreta, Antonella Consiglio, Federico Gonzalez, Rita Vassena, Josipa Bilić, Vladimir Pekarik, Gustavo Tiscornia, Michael Edel, Stéphanie Boué, Juan Carlos Izpisúa Belmonte, Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes. Nature Biotechnology. ,vol. 26, pp. 1276- 1284 ,(2008) , 10.1038/NBT.1503
M. K. Furue, J. Na, J. P. Jackson, T. Okamoto, M. Jones, D. Baker, R.-I. Hata, H. D. Moore, J. D. Sato, P. W. Andrews, Heparin promotes the growth of human embryonic stem cells in a defined serum-free medium Proceedings of the National Academy of Sciences of the United States of America. ,vol. 105, pp. 13409- 13414 ,(2008) , 10.1073/PNAS.0806136105
I. Wilmut, A.E. Schnieke, J. McWhir, A.J. Kind, K.H.S. Campbell, Viable offspring derived from fetal and adult mammalian cells. Cloning and Stem Cells. ,vol. 9, pp. 3- 7 ,(2007) , 10.1089/CLO.2006.0002
S Watanabe, H Umehara, K Murayama, M Okabe, T Kimura, T Nakano, Activation of Akt signaling is sufficient to maintain pluripotency in mouse and primate embryonic stem cells. Oncogene. ,vol. 25, pp. 2697- 2707 ,(2006) , 10.1038/SJ.ONC.1209307
In-Hyun Park, Rui Zhao, Jason A. West, Akiko Yabuuchi, Hongguang Huo, Tan A. Ince, Paul H. Lerou, M. William Lensch, George Q. Daley, Reprogramming of human somatic cells to pluripotency with defined factors Nature. ,vol. 451, pp. 141- 146 ,(2008) , 10.1038/NATURE06534