Unimpaired effect of insulin on glucokinase gene expression in hepatocytes challenged with amylin

摘要: Amylin appears to interfere with the action of insulin in muscle and possibly liver. We have attempted detect a direct antagonism between amylin cultured rat hepatocytes. The stimulation glucokinase gene expression was used as marker action. proved ineffective suppressing subsequent accumulation mRNA response maximal or submaximal doses insulin. When applied cells already induced by prior incubation alone, failed reverse induction, contrast effectiveness glucagon under same conditions. Thus, is not physiological antagonist control hepatic expression.