Cytochrome P450 1A1 (CYP1A1) polymorphism and susceptibility to esophageal cancer: an updated meta-analysis of 27 studies
作者： Feng-Feng Gong , Shan-Shan Lu , Cai-Yun Hu , Zhen-Zhong Qian , Fang Feng
DOI: 10.1007/S13277-014-2341-Y
关键词: Pathology 、 Odds ratio 、 Medicine 、 Metastasis 、 Esophageal cancer 、 Population 、 Gene polymorphism 、 Genetic model 、 Internal medicine 、 Gastroenterology 、 Subgroup analysis 、 Meta-analysis
摘要: Cytochrome P450 1A1 (CYP1A1) polymorphisms are known to play a crucial role in the development and metastasis of malignant diseases including esophageal cancer. However, results previous studies investigating association between CYP1A1 cancer risk have been inconsistent. This meta-analysis 27 eligible studies, encompassing 4,215 cases 6,339 control subjects, pooled odds ratios (ORs) with corresponding 95 % confidence intervals (95 CI) assess this association. The effects ethnicity (Caucasian Asian) histopathology type (esophageal squamous cell carcinoma adenocarcinoma) were considered subgroup analyses. A significant was observed Ile/Val gene polymorphism all genetic models (Ile/Val vs. Ile/Ile, OR = 1.41, CI 1.25–1.58; Val/Val 1.94, 1.34–2.82; + 1.49, 1.33–1.66). analysis based on showed that existed Asian Caucasian populations. no MspI either or overall population. These suggested associated an increased cancer, whereas may not susceptibility Further required confirm these findings.
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