The phylogeny of rodent malaria parasites: simultaneous analysis across three genomes.

摘要: Abstract Species of Plasmodium that naturally infect wild rodents but can also be maintained in laboratory mice have long been used as model systems which to study the biology malaria parasites. Several these rodent parasites are now providing useful genomic comparisons those species cause humans. Here we examined phylogenetic relationships 19 strains including four native African thicket rats ( berghei , chabaudi vinckei and yoelii ) one from a porcupine atheruri using DNA sequence data collected seven genes each three parasite genomes. These included nuclear dihydrofolate reductase gene cysteine protease gene, mitochondrial cytochrome b oxidase I genes, elongation factor tufA caseinolytic C, “open reading frame 470” apicoplast genome, for combined total 5049 nucleotides. Using simultaneous analysis, method combining partitions into super-matrix, two equally parsimonious trees were recovered. Bayesian analysis dataset produced same topology. The basic groups well supported, with exception placement P. within clade. Named subspecies showed wide array genetic differentiation, fell monophyletic groups.