Effect of hydroxyethyl starch 130/0.4 and 200/0.5 solutions on canine platelet function in vitro
作者： Duana McBride , Giselle L. Hosgood , Caroline S. Mansfield , Lisa Smart
关键词: Hetastarch 、 Anesthesia 、 Hydroxyethyl Starch Derivatives 、 Dilution 、 Saline 、 Platelet 、 In vivo 、 Serial dilution 、 Hydroxyethyl starch 、 Chromatography 、 Chemistry
摘要: Objective—To determine whether dilution of blood samples from healthy dogs with 2 hydroxyethyl starch (HES) solutions, HES 130/0.4 and 200/0.5, would result in platelet dysfunction as measured by closure time (Ct) beyond a dilutional effect. Sample—Citrated 10 Ct within reference limits (52 to 86 seconds). Procedures—Blood were diluted 1:9 1:3 6% 10% 200/0.5 solutions saline (0.9% NaCl) solution. Dilutions at mimicked mL/kg 30 doses, respectively, ignoring vivo redistribution. Closure was function analyzer compared among dilutions. Results—A effect on evident for the dilution, but only increased median 125 seconds (interquartile range, 117.5 139.5 No or identified dilution. ...
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