Autoantibodies against cytoskeletal proteins in rheumatoid arthritis.
作者： M. Shrivastav* , B. Mittal , A. Aggarwal , R. Misra
关键词: Anti-SSA/Ro autoantibodies 、 Rheumatology 、 Immunology 、 Internal medicine 、 Pathology 、 Myosin 、 Antigen 、 Medicine 、 Immunofluorescence 、 Autoantibody 、 Cytoskeleton 、 Rheumatoid arthritis
摘要: We determined the prevalence and antigenic specificity of autoantibodies against cytoskeletal proteins in patients affected with various autoimmune diseases. Sera collected from rheumatoid arthritis, systemic lupus erythematosus or progressive sclerosis, normal volunteers, were examined for presence by indirect immunofluorescence enzyme-linked immunosorbent assay (ELISA). Patients arthritis had highest reactivity to antigens on assays using isolated muscle myofibrils (41/50) L929 cells (37/50). Antigen-specific ELISA revealed significant immunoreactivity actin (11/50) myosin (15/50). In nine patients, was seen multiple antigens. concluded that IgG antigens, especially myofibrillar components myosin, is elevated arthritis.
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