Genome analysis of clinical multilocus sequence Type 11 Klebsiella pneumoniae from China.

摘要: The increasing prevalence of KPC-producing Klebsiella pneumoniae strains in clinical settings has been largely attributed to dissemination organisms specific multilocus sequence types, such as ST258 and ST11. Compared with the clone, which is prevalent North America Europe, ST11 common China but information regarding its genetic features remains scarce. In this study, we performed detailed characterization K. by analyzing whole-genome sequences 58 collected from diverse geographic locations China. genomes were found be highly heterogeneous clustered into at least three major lineages based on patterns single-nucleotide polymorphisms. Exhibiting five different capsular these harbor multiple resistance virulence determinants blaKPC-2 gene, encodes carbapenemase, yersiniabactin-associated genes irp, ybt fyu. Moreover, encoding factor aerobactin regulator mucoid phenotype (rmpA) detectable six genomes, whereas salmochelin genomes. conclusion, our data indicated that carriage a wide range constitutes underlying basis high level settings. Such findings provide insight development novel strategies for prevention, diagnosis treatment infections.