Bone stiffness and failure load are related with clinical parameters in men with chronic obstructive pulmonary disease

摘要: Osteoporosis is frequently seen in patients with chronic obstructive pulmonary disease (COPD). Because research on bone structure and strength COPD limited, the objectives of this pilot study were as follows: (1) to compare structure, stiffness, failure load, measured at peripheral skeleton, between men without after stratification for areal mineral density (aBMD); (2) relate clinical parameters stiffness load COPD. We included 30 (normal aBMD, n = 18; osteoporosis, n = 12) 17 n = 9; n = 8). assessed pack-years smoking, body mass index (BMI), fat free (FFMI), function (forced expiratory volume 1 second [FEV1], FEV1/forced vital capacity [FVC], diffusion carbon monoxide [DLCO], transfer coefficient [KCO]), extent emphysema. Bone distal radius tibia was by high-resolution quantitative computed tomography (HR-pQCT), estimated from micro finite element analysis (µFEA). After aBMD COPD, osteoporosis showed abnormal (p < 0.01), lower (p < 0.01) compared normal had comparable In FFMI related DLCO KCO normalization respect femoral neck aBMD. Thus, could not detect differences gas lung significantly © 2013 American Society Mineral Research.