Bone micro-architecture and determinants of strength in the radius and tibia: age-related changes in a population-based study of normal adults measured with high-resolution pQCT

摘要: We recruited a population-based sample of 58 males and 74 females aged 20–79 from primary care medical practice to provide normative descriptive data for high-resolution peripheral quantitative computed tomography (pQCT) parameters. Important effects ageing contrasts in the sex on micro-architecture strength upper lower limb bones were revealed. The advent pQCT scanners has permitted non-invasive assessment structural cortical trabecular bone. investigated age-related changes finite element (FE) modelling parameters at distal radius tibia cross-sectional study 20–79 years. Linear regression models including quadratic terms age used inference. Age-related differences generally similar tibia. At each site, mean values bone density, thickness (number, separation thickness) (trabecular higher) women than men. Changes with most apparent density thickness, which declined age, contrast not significantly associated (p > 0.05) either sex. Cortical faster men after 50 was consistently women. FE-analysis predicted failure load decreased percentage carried by increased (p < 0.05). These show ageing. decline have implications excess risks wrist hip fractures